MLH1 anticorps

N° du produit ABIN379237

Cet anticorps anti-MLH1 est un anticorps Souris Monoclonal détectant MLH1 dans IHC et IHC (p). Adapté pour Humain, Rat et Hamster.

Aperçu rapide pour MLH1 anticorps (ABIN379237)

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Reactivité: Humain, Rat, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLH1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: G168-15

Détail du produit anti-MLH1 anticorps

Specificité: The G168-15 antibody recognizes the human and mouse MLH1 (80-85  kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat

Immunogène: Full length recombinant MLH.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid containing sodium azide as a preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur MLH1

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Autre désignation: MLH1

Sujet: Name/Gene ID: MLH1

Synonyms: MLH1, COCA2, FCC2, HMLH1, HNPCC, HNPCC2, MutL protein homolog 1

ID gène: 4292

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response