Kdm6b anticorps (AA 954-987)

N° du produit ABIN387864

Cet anticorps anti-Kdm6b est un anticorps Lapin Polyclonal détectant Kdm6b dans WB. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour Kdm6b anticorps (AA 954-987) (ABIN387864)

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kdm6b est non-conjugé

Application: Western Blotting (WB)

Clone: RB10080

Détail du produit anti-Kdm6b anticorps

Épitope: AA 954-987

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the Central region of mouse JMJD3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Kdm6b (ABIN387864)

Shaw, Martin: "Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes." dans: EMBO reports, Vol. 10, Issue 8, pp. 881-6, (2009) (PubMed).

Détails sur Kdm6b

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Autre désignation: JMJD3

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Poids moléculaire: 176355

ID gène: 216850

NCBI Accession: NP_001017426

UniProt: Q5NCY0

Pathways: L'effet Warburg