KDM3B anticorps (N-Term)

N° du produit ABIN387870

Cet anticorps anti-KDM3B est un anticorps Lapin Polyclonal détectant KDM3B dans WB. Adapté pour Humain.

Aperçu rapide pour KDM3B anticorps (N-Term) (ABIN387870)

Antigène: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM3B est non-conjugé

Application: Western Blotting (WB)

Clone: RB10782

Détail du produit anti-KDM3B anticorps

Épitope: AA 25-57, N-Term

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This JMJD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-57 amino acids from the N-terminal region of human JMJD1B.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur KDM3B

Antigène: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Autre désignation: JMJD1B

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Poids moléculaire: 191581

ID gène: 51780

NCBI Accession: NP_057688

UniProt: Q7LBC6

Pathways: L'effet Warburg