JMJD4 anticorps (C-Term)

N° du produit ABIN387875

L’anticorps Lapin Polyclonal anti-JMJD4 a été validé pour WB et IHC (p). Il convient pour détecter JMJD4 dans des échantillons de Humain et Souris.

Aperçu rapide pour JMJD4 anticorps (C-Term) (ABIN387875)

Antigène: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMJD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB10802

Détail du produit anti-JMJD4 anticorps

Épitope: AA 423-455, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-455 amino acids from the C-terminal region of human JMJD4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur JMJD4

Antigène: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Autre désignation: JMJD4

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Poids moléculaire: 52493

ID gène: 65094

NCBI Accession: NP_001154937, NP_075383

UniProt: Q9H9V9