HDAC11 anticorps (C-Term)

N° du produit ABIN387965

L’anticorps Lapin Polyclonal anti-HDAC11 a été validé pour WB et IHC (p). Il convient pour détecter HDAC11 dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour HDAC11 anticorps (C-Term) (ABIN387965)

Antigène: HDAC11 (Histone Deacetylase 11 (HDAC11))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2589

Détail du produit anti-HDAC11 anticorps

Épitope: AA 313-345, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-HDAC11 (ABIN387965)

Joshi, Greco, Guise, Luo, Yu, Nesvizhskii, Cristea: "The functional interactome landscape of the human histone deacetylase family." dans: Molecular systems biology, Vol. 9, pp. 672, (2013) (PubMed).

Keedy, Archin, Gates, Espeseth, Hazuda, Margolis: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." dans: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, (2009) (PubMed).

Détails sur HDAC11

Antigène: HDAC11 (Histone Deacetylase 11 (HDAC11))

Autre désignation: HDAC11

Sujet: HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Poids moléculaire: 39183

ID gène: 79885

NCBI Accession: NP_001129513, NP_079103

UniProt: Q96DB2