MAP1LC3A anticorps

N° du produit ABIN388463

L’anticorps Lapin Polyclonal anti-MAP1LC3A a été validé pour WB et IF. Il convient pour détecter MAP1LC3A dans des échantillons de Humain. Il y a 9+ publications disponibles.

Aperçu rapide pour MAP1LC3A anticorps (ABIN388463)

Antigène: MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP1LC3A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: RB7993

Détail du produit anti-MAP1LC3A anticorps

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This LC3 antibody is generated from rabbits immunized with full-length recombinant human LC3 (APG8a).

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:200. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MAP1LC3A (ABIN388463)

Want, Gillespie, Wang, Gordon, Iomini, Ritch, Wolosin, Bernstein: "Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients." dans: PLoS ONE, Vol. 11, Issue 7, pp. e0157404, (2017) (PubMed).

Hu, Wu, Ding, Zhang: "Thrombin preferentially induces autophagy in glia cells in the rat central nervous system." dans: Neuroscience letters, Vol. 630, pp. 53-58, (2017) (PubMed).

Wu, Hong, Wang, Huang, Yeh, Wang, Wang, Chiu: "A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer." dans: Cancer letters, Vol. 400, pp. 79-88, (2017) (PubMed).

Islam, Shin, Yun, Cho, Seo, Chae, Cho: "The effect of RNAi silencing of p62 using an osmotic polysorbitol transporter on autophagy and tumorigenesis in lungs of K-rasLA1 mice." dans: Biomaterials, Vol. 35, Issue 5, pp. 1584-96, (2013) (PubMed).

Liu, Jia, Zhang, Hou, Wang, Hao, Ruan, Yu, Zheng: "Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival." dans: International immunopharmacology, Vol. 12, Issue 2, pp. 394-401, (2012) (PubMed).

Zhang, Morgan, Chen, Choksi, Liu: "Induction of autophagy is essential for monocyte-macrophage differentiation." dans: Blood, Vol. 119, Issue 12, pp. 2895-905, (2012) (PubMed).

Wojtkowiak, Sane, Kleinman, Sloane, Reiners, Mattingly: "Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin." dans: The Journal of pharmacology and experimental therapeutics, Vol. 337, Issue 1, pp. 65-74, (2011) (PubMed).

Mizuno, Yasuo, Bogaard, Kraskauskas, Natarajan, Voelkel: "Inhibition of histone deacetylase causes emphysema." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 300, Issue 3, pp. L402-13, (2011) (PubMed).

Zheng, Liu, Li, Xu, Xu: "RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats." dans: Acta pharmacologica Sinica, Vol. 30, Issue 7, pp. 919-27, (2009) (PubMed).

Détails sur MAP1LC3A

Antigène: MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

Autre désignation: LC3

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

ID gène: 84557

NCBI Accession: NP_115903, NP_852610

UniProt: Q9H492, Q9GZQ8

Pathways: Autophagy