UVRAG anticorps (C-Term)

N° du produit ABIN388586

L’anticorps Lapin Polyclonal anti-UVRAG a été validé pour WB, IF et IHC (p). Il convient pour détecter UVRAG dans des échantillons de Humain et Souris. Il y a 7+ publications disponibles.

Aperçu rapide pour UVRAG anticorps (C-Term) (ABIN388586)

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UVRAG est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB10849

Détail du produit anti-UVRAG anticorps

Épitope: AA 666-699, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 amino acids from the C-terminal region of human UVRAG.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. IF: 1:200. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-UVRAG (ABIN388586)

Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, (2011) (PubMed).

Sun, Zhang, Fan, Wong, Ding, Chen, Zhong: "The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression." dans: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 185-91, (2011) (PubMed).

Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

Sun, Westphal, Wong, Tan, Zhong: "Rubicon controls endosome maturation as a Rab7 effector." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 45, pp. 19338-43, (2010) (PubMed).

Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." dans: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, (2010) (PubMed).

Sun, Fan, Chen, Ding, Chen, Zhong: "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 49, pp. 19211-6, (2008) (PubMed).

Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: "Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells." dans: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19665-77, (2008) (PubMed).

Détails sur UVRAG

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Autre désignation: UVRAG

Sujet: UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Poids moléculaire: 78151

ID gène: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5