BMI1 anticorps (C-Term)

N° du produit ABIN389084

L’anticorps Lapin Polyclonal anti-BMI1 a été validé pour WB et IHC (p). Il convient pour détecter BMI1 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour BMI1 anticorps (C-Term) (ABIN389084)

Antigène: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMI1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB02926

Détail du produit anti-BMI1 anticorps

Épitope: AA 257-286, C-Term

Homologie: B, C, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-BMI1 (ABIN389084)

Wang, Venugopal, Manoranjan, McFarlane, OFarrell, Nolte, Gunnarsson, Hollenberg, Kwiecien, Northcott, Taylor, Hawkins, Singh: "Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells." dans: Oncogene, Vol. 31, Issue 2, pp. 187-99, (2012) (PubMed).

Lewis, Segditsas, Deheragoda, Pollard, Jeffery, Nye, Lockstone, Davis, Clark, Stamp, Poulsom, Wright, Tomlinson: "Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5." dans: Gut, Vol. 59, Issue 12, pp. 1680-6, (2010) (PubMed).

Sangiorgi, Capecchi: "Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 17, pp. 7101-6, (2009) (PubMed).

Détails sur BMI1

Antigène: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Autre désignation: BMI1

Sujet: BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.

Poids moléculaire: 36949

ID gène: 648

NCBI Accession: NP_001190991, NP_005171

UniProt: P35226

Pathways: Cycle Cellulaire, Autophagy