CBX4 anticorps (N-Term)

N° du produit ABIN389086

Cet anticorps Lapin Polyclonal détecte spécifiquement CBX4 dans WB et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 2+ publications.

Aperçu rapide pour CBX4 anticorps (N-Term) (ABIN389086)

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2931

Détail du produit anti-CBX4 anticorps

Épitope: AA 80-110, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PC2 (CBX4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 amino acids from the N-terminal region of human PC2 (CBX4).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CBX4 (ABIN389086)

Oh, Kim, Mouradian, Chung: "Human Polycomb protein 2 promotes ?-synuclein aggregate formation through covalent SUMOylation." dans: Brain research, Vol. 1381, pp. 78-89, (2011) (PubMed).

Yang, Sharrocks: "The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif." dans: Molecular and cellular biology, Vol. 30, Issue 9, pp. 2193-205, (2010) (PubMed).

Détails sur CBX4

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Autre désignation: PC2 (CBX4)

Sujet: CBX4 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators, changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. CBX4 is part of acomplex that acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.

Poids moléculaire: 61368

ID gène: 8535

NCBI Accession: NP_003646

UniProt: O00257