CBX4 anticorps (C-Term)

N° du produit ABIN389087

L’anticorps Lapin Polyclonal anti-CBX4 a été validé pour WB. Il convient pour détecter CBX4 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour CBX4 anticorps (C-Term) (ABIN389087)

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX4 est non-conjugé

Application: Western Blotting (WB)

Clone: RB2934

Détail du produit anti-CBX4 anticorps

Épitope: AA 410-437, C-Term

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CBX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-437 amino acids from the C-terminal region of human CBX4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CBX4 (ABIN389087)

Vincenz, Kerppola: "Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 43, pp. 16572-7, (2008) (PubMed).

Jones, Fusi, Higham, Abdel-Hafiz, Horwitz, Lam, Brosens: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).

Détails sur CBX4

Antigène: CBX4 (Chromobox Homolog 4 (CBX4))

Autre désignation: CBX4

Sujet: Chromobox homolog 4 (CBX4 or Pc2) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system that is responsible for the inheritance of gene activity by progeny cells. CBX4 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain. It was reported that Pc2 is involved in sumoylation process by recruiting SUMO E1 and E2, and Pc2 is actually SUMO E3 during sumoylation events. CBX4 expression is ubiquitous.

Poids moléculaire: 61368

ID gène: 8535

NCBI Accession: NP_003646

UniProt: O00257