CDC25A anticorps (pSer124)

N° du produit ABIN389527

Cet anticorps Lapin Polyclonal détecte spécifiquement CDC25A dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 2+ publications.

Aperçu rapide pour CDC25A anticorps (pSer124) (ABIN389527)

Antigène: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC25A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB07634

Détail du produit anti-CDC25A anticorps

Épitope: pSer124

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S124 of human CDC25A.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500. WB: 1:500. WB: 1:500. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-CDC25A (ABIN389527)

Zoppoli, Solier, Reinhold, Liu, Connelly, Monks, Shoemaker, Abaan, Davis, Meltzer, Doroshow, Pommier: "CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute." dans: Oncogene, Vol. 31, Issue 4, pp. 403-18, (2012) (PubMed).

Solier, Sordet, Kohn, Pommier: "Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways." dans: Molecular and cellular biology, Vol. 29, Issue 1, pp. 68-82, (2008) (PubMed).

Détails sur CDC25A

Antigène: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Autre désignation: CDC25A

Sujet: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 59087

ID gène: 993

NCBI Accession: NP_001780, NP_963861

UniProt: P30304

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, M Phase