Retinoblastoma 1 anticorps (pSer788)

N° du produit ABIN389645

L’anticorps Lapin Polyclonal anti-Retinoblastoma 1 a été validé pour IHC (p) et DB. Il convient pour détecter Retinoblastoma 1 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour Retinoblastoma 1 anticorps (pSer788) (ABIN389645)

Antigène: Retinoblastoma 1 (RB1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Clone: RB7670

Détail du produit anti-Retinoblastoma 1 anticorps

Épitope: pSer788

Specificité: This Phospho-Rb-S788 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Rb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB = 1:500, IHC (p) = 1:50-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.45 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Retinoblastoma 1 (ABIN389645)

Iwahori, Hakki, Chou, Kalejta: "Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97." dans: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19666-80, (2015) (PubMed).

Détails sur Retinoblastoma 1

Antigène: Retinoblastoma 1 (RB1)

Autre désignation: Rb

Sujet: RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
Synonyms: Retinoblastoma-associated protein, PP110, P105-RB, RB, RB1,

Poids moléculaire: 106159 DA

ID gène: 5925

UniProt: P06400

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy