MMP12 anticorps (C-Term)

N° du produit ABIN390136

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP12 dans WB, IHC (p) et IF. Il présente une réactivité avec des échantillons de Humain et Souris. Il a été cité dans 3+ publications.

Aperçu rapide pour MMP12 anticorps (C-Term) (ABIN390136)

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: RB2026

Détail du produit anti-MMP12 anticorps

Épitope: AA 391-420, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MMP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:2000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MMP12 (ABIN390136)

Du, Wang, Tan, Li, Huang, Huang, Yang, Zhang, Wang, Huang, Huang: "Nkx2-5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E-Deficient Mice." dans: Journal of the American Heart Association, Vol. 5, Issue 12, (2017) (PubMed).

LaPan, Brady, Grierson, Fleming, Miller, Sypek, Fu: "Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum." dans: BMC pulmonary medicine, Vol. 10, pp. 40, (2010) (PubMed).

Ma, Flanc, Tesch, Bennett, Friedman, Nikolic-Paterson: "Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 89, Issue 4, pp. 470-84, (2009) (PubMed).

Détails sur MMP12

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Autre désignation: MMP12

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.

Poids moléculaire: 54002

ID gène: 4321

NCBI Accession: NP_002417

UniProt: P39900