BCKDK anticorps (C-Term)

N° du produit ABIN391130

L’anticorps Lapin Polyclonal anti-BCKDK a été validé pour WB. Il convient pour détecter BCKDK dans des échantillons de Humain et Souris.

Aperçu rapide pour BCKDK anticorps (C-Term) (ABIN391130)

Antigène: BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase (BCKDK))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCKDK est non-conjugé

Application: Western Blotting (WB)

Clone: RB5257

Détail du produit anti-BCKDK anticorps

Épitope: AA 325-356, C-Term

Homologie: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This BCKDK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-356 amino acids from the C-terminal region of human BCKDK.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur BCKDK

Antigène: BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase (BCKDK))

Autre désignation: BCKDK

Sujet: The second major step in the catabolism of the branched-chain amino acids, isoleucine, leucine, and valine, is irreversibly catalyzed by the branched-chain alpha-keto acid dehydrogenase complex (BCKD), an inner-mitochondrial enzyme complex composed of 3 catalytic components: a branched-chain alpha-keto acid decarboxylase (E1), a dihydrolipoyl transacylase (E2), and a dihydrolipoamide dehydrogenase (E3). The complex also contains 2 enzymes that regulated the state of activity of the BCKD complex: a kinase (BCKDK), and a phosphorylase. The ubiquitiously expressed kinase contains 1 histidine kinase domain. Maple syrup urine disease (MSUD) is a pathology secondary to an enzyme defect in the catabolic pathway of leucine, isoleucine, and valine. Accumulation of these amino acids and their corresponding keto acids results in encephalopathy and progressive neurodegeneration in infants not treated for MSUD.

Poids moléculaire: 46360

ID gène: 10295

NCBI Accession: NP_001116429, NP_005872

UniProt: O14874

Pathways: SARS-CoV-2 Protein Interactome