ERN2 anticorps (N-Term)

N° du produit ABIN391194

Détail du produit anti-ERN2 anticorps

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Épitope: AA 39-72, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.

Clone: RB8519

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur ERN2

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Autre désignation: ERN2 (ERN2 Produits)

Synonymes: anticorps Ire1beta, anticorps ire1b, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps IRE1-BETA, anticorps IRE1b, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN2, anticorps ern2, anticorps Ern2

Sujet: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Poids moléculaire: 102480

ID gène: 10595

NCBI Accession: NP_150296

UniProt: Q76MJ5