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ERN2 anticorps

ERN2 Reactivité: Humain ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7238930
  • Antigène Voir toutes ERN2 Anticorps
    ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
    Reactivité
    • 28
    • 19
    Humain
    Hôte
    • 43
    • 1
    Lapin
    Clonalité
    • 44
    Polyclonal
    Conjugué
    • 17
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ERN2 est non-conjugé
    Application
    • 32
    • 30
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    Synthetic peptide of human ERN2
    Isotype
    IgG
  • Indications d'application
    IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))
    Autre désignation
    ERN2 (ERN2 Produits)
    Synonymes
    anticorps Ire1beta, anticorps ire1b, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps IRE1-BETA, anticorps IRE1b, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN2, anticorps ern2, anticorps Ern2
    Sujet
    The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
    NCBI Accession
    NP_150296
    UniProt
    Q76MJ5
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