NME3 anticorps (AA 51-81)

N° du produit ABIN391232

Détail du produit anti-NME3 anticorps

Antigène: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Épitope: AA 51-81

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NME3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

Clone: RB5454

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur NME3

Antigène: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Autre désignation: NME3 (NME3 Produits)

Synonymes: anticorps DR-nm23, anticorps NDPK-C, anticorps NDPKC, anticorps NM23-H3, anticorps NM23H3, anticorps c371H6.2, anticorps 1810009F08Rik, anticorps AI413736, anticorps Ndk3, anticorps Nm23-DR, anticorps Nm23-M3, anticorps NME/NM23 nucleoside diphosphate kinase 3, anticorps NME3, anticorps Nme3

Sujet: NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

Poids moléculaire: 19015

ID gène: 4832

NCBI Accession: NP_002504

UniProt: Q13232

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process