SPHK2 anticorps (C-Term)

N° du produit ABIN391349

L’anticorps Lapin Polyclonal anti-SPHK2 a été validé pour WB et IHC (p). Il convient pour détecter SPHK2 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour SPHK2 anticorps (C-Term) (ABIN391349)

Antigène: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPHK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB03625

Détail du produit anti-SPHK2 anticorps

Épitope: AA 590-620, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-620 amino acids from the C-terminal region of human SPHK2.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:250. IHC-P-Leica: 1:250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-SPHK2 (ABIN391349)

Sun, Zhang, Wang, Wang, Ma, Lei, Zhou, Sun, Lu, Liu, Han: "Down-regulation of Sphk2 suppresses bladder cancer progression." dans: Tumour biology, (2015) (PubMed).

Coste, Brenneis, Linke, Pierre, Maeurer, Becker, Schmidt, Gao, Geisslinger, Scholich: "Sphingosine 1-phosphate modulates spinal nociceptive processing." dans: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32442-51, (2008) (PubMed).

Détails sur SPHK2

Antigène: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Autre désignation: SPHK2

Sujet: Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Poids moléculaire: 69217

NCBI Accession: NP_001191087, NP_001191088, NP_001191089, NP_064511

UniProt: Q9NRA0

Pathways: VEGF Signaling