Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

SPHK2 anticorps (C-Term)

SPHK2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB03625 unconjugated
N° du produit ABIN391349
  • Antigène Voir toutes SPHK2 Anticorps
    SPHK2 (Sphingosine Kinase 2 (SPHK2))
    Épitope
    • 15
    • 11
    • 10
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 590-620, C-Term
    Reactivité
    • 64
    • 27
    • 25
    Humain
    Hôte
    • 61
    • 3
    Lapin
    Clonalité
    • 63
    • 1
    Polyclonal
    Conjugué
    • 34
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SPHK2 est non-conjugé
    Application
    • 43
    • 36
    • 32
    • 13
    • 13
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-620 amino acids from the C-terminal region of human SPHK2.
    Clone
    RB03625
    Isotype
    IgG
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:250. IHC-P-Leica: 1:250
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze-thaw cycles.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Date de péremption
    6 months
  • Sun, Zhang, Wang, Wang, Ma, Lei, Zhou, Sun, Lu, Liu, Han: "Down-regulation of Sphk2 suppresses bladder cancer progression." dans: Tumour biology, (2015) (PubMed).

    Coste, Brenneis, Linke, Pierre, Maeurer, Becker, Schmidt, Gao, Geisslinger, Scholich: "Sphingosine 1-phosphate modulates spinal nociceptive processing." dans: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32442-51, (2008) (PubMed).

  • Antigène
    SPHK2 (Sphingosine Kinase 2 (SPHK2))
    Autre désignation
    SPHK2 (SPHK2 Produits)
    Synonymes
    anticorps CG2159, anticorps CG32484, anticorps Dmel\\CG32484, anticorps SK2, anticorps Sphk2, anticorps sk2, anticorps DKFZp469F224, anticorps SK 2, anticorps SK-2, anticorps SPK 2, anticorps SPK-2, anticorps C76851, anticorps Sphingosine kinase, anticorps sphk2, anticorps Sphingosine kinase 2, anticorps sphingosine kinase 2, anticorps sphK2, anticorps Sk2, anticorps SPHK2, anticorps Sphk2
    Sujet
    Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
    Poids moléculaire
    69217
    NCBI Accession
    NP_001191087, NP_001191088, NP_001191089, NP_064511
    UniProt
    Q9NRA0
    Pathways
    VEGF Signaling
Vous êtes ici:
Support technique