PTTG1 anticorps (N-Term)

N° du produit ABIN391532

L’anticorps Lapin Polyclonal anti-PTTG1 a été validé pour WB, IF et IHC (p). Il convient pour détecter PTTG1 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour PTTG1 anticorps (N-Term) (ABIN391532)

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTTG1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB18596

Détail du produit anti-PTTG1 anticorps

Épitope: AA 16-45, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PTTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human PTTG1.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:100. WB: 1:500. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PTTG1 (ABIN391532)

Cui, Xu, Song, Zhao, Liu, Song: "Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment." dans: Acta biochimica et biophysica Sinica, Vol. 47, Issue 6, pp. 414-21, (2015) (PubMed).

Détails sur PTTG1

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Autre désignation: PTTG1

Sujet: PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.

Poids moléculaire: 22024

ID gène: 9232

NCBI Accession: NP_001269311, NP_001269312, NP_004210

UniProt: O95997