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CDK4 anticorps (C-Term)
CDK4
Reactivité: Humain
WB, IF, FACS, IHC (p)
Hôte: Lapin
Polyclonal
RB03154
unconjugated
Détail du produit anti-CDK4 anticorps
(cache)
Antigène
Voir toutes CDK4 Anticorps
CDK4
(Cyclin-Dependent Kinase 4 (CDK4))
Épitope
Tous les épitopes à travers CDK4 Anticorps.
AA 273-305, C-Term
Reactivité
Toutes les réactivités sur CDK4 Anticorps
Humain
Hôte
Toutes les hôtes sur CDK4 Anticorps
Lapin
Clonalité
Toutes les clonalités sur CDK4 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers CDK4 Anticorps
Cet anticorp CDK4 est non-conjugé
Application
Tous les applications à travers CDK4 Anticorps.
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This CDK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-305 amino acids from the C-terminal region of human CDK4.
Clone
RB03154
Isotype
Ig Fraction
Alternatives
(show)
Information d'application
(cache)
Indications d'application
IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100. FC: 1:10~50
Restrictions
For Research Use only
Stockage
(cache)
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Références pour anticorps anti-CDK4 (ABIN391751)
(cache)
Ling, Song, Fan, Feng, Liu, Yang, Wang, Li, Tian, Zhao, Liu, Huang, Hou, Xu, Shi, Li : "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway. " dans: International journal of oncology , Vol. 50 , Issue 1 , pp. 297-309 , (2017 ) (PubMed ).
Patel, Asbach, Shteyn, Gomez, Coltoff, Bhuyan, Tyner, Wagner, Blain : "Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4. " dans: Molecular and cellular biology , Vol. 35 , Issue 9 , pp. 1506-22 , (2015 ) (PubMed ).
Ling, Feng, Ke, Fan, Li, Li, Dong, Wang, Xu, Li, Wang : "Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines. " dans: Oncology reports , Vol. 31 , Issue 6 , pp. 2611-8 , (2014 ) (PubMed ).
Détails sur CDK4
(cache)
Antigène
CDK4
(Cyclin-Dependent Kinase 4 (CDK4))
Autre désignation
CDK4 (CDK4 Produits )
Synonymes
anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
Sujet
CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.
Poids moléculaire
33730
ID gène
1019
NCBI Accession
NP_000066
UniProt
P11802
Pathways
Cycle Cellulaire , Mitotic G1-G1/S Phases , Regulation of Cell Size
Vus récemment
(cache)