EPH Receptor A3 anticorps (C-Term)

N° du produit ABIN391888

Cet anticorps Lapin Polyclonal détecte spécifiquement EPH Receptor A3 dans WB et IHC (p). Il présente une réactivité envers Humain et Hamster et a été mentionné dans 1 publication.

Aperçu rapide pour EPH Receptor A3 anticorps (C-Term) (ABIN391888)

Antigène: EPH Receptor A3 (EPHA3)

Reactivité: Humain, Hamster

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1585

Détail du produit anti-EPH Receptor A3 anticorps

Épitope: AA 896-928, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This EphA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 896-928 amino acids from the C-terminal region of human EphA3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-EPH Receptor A3 (ABIN391888)

Wang, Xu, Cao, Wu, Wang: "Loss of EphA3 Protein Expression Is Associated With Advanced TNM Stage in Clear-Cell Renal Cell Carcinoma." dans: Clinical genitourinary cancer, Vol. 15, Issue 2, pp. e169-e173, (2017) (PubMed).

Détails sur EPH Receptor A3

Antigène: EPH Receptor A3 (EPHA3)

Autre désignation: EphA3

Sujet: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Poids moléculaire: 110131

ID gène: 2042

NCBI Accession: NP_005224, NP_872585

UniProt: P29320

Pathways: Signalisation RTK, Regulation of Cell Size