PLK3 anticorps (C-Term)

N° du produit ABIN392602

Cet anticorps Lapin Polyclonal détecte spécifiquement PLK3 dans WB. Il présente une réactivité envers Humain et Souris et a été mentionné dans 1 publication.

Aperçu rapide pour PLK3 anticorps (C-Term) (ABIN392602)

Antigène: PLK3 (Polo-Like Kinase 3 (PLK3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLK3 est non-conjugé

Application: Western Blotting (WB)

Clone: RB0875

Détail du produit anti-PLK3 anticorps

Épitope: AA 615-646, C-Term

Homologie: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 615-646 amino acids from the C-terminal region of human PLK3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PLK3 (ABIN392602)

Zhang, Shi, Paddon, Hampong, Dai, Pelech: "B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1." dans: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35726-34, (2004) (PubMed).

Détails sur PLK3

Antigène: PLK3 (Polo-Like Kinase 3 (PLK3))

Autre désignation: PLK3

Sujet: CNK, a member of the CDC5/Polo subfamily of Ser/Thr protein kinases, is involved in regulating M phase functions during the cell cycle. It may also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein. This membrane-associated protein binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. This protein exhibits a short half-live. In cells of hematopoietic origin, CNK is strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Cytokine and cellular adhesion trigger CNK induction. CNK is thought to be phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis The protein contains 2 POLO box domains.

Poids moléculaire: 71629

ID gène: 1263

NCBI Accession: NP_004064

UniProt: Q9H4B4

Pathways: Regulation of long-term Neuronal Synaptic Plasticity