Hexokinase 1 anticorps (N-Term)

N° du produit ABIN392759

L’anticorps Lapin Polyclonal anti-Hexokinase 1 a été validé pour WB et IHC (p). Il convient pour détecter Hexokinase 1 dans des échantillons de Humain et Rat. Il y a 1 publication disponible.

Aperçu rapide pour Hexokinase 1 anticorps (N-Term) (ABIN392759)

Antigène: Hexokinase 1 (HK1)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Hexokinase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3921-RB3922

Détail du produit anti-Hexokinase 1 anticorps

Épitope: AA 78-108, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HK1 (Hexokinase) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human HK1 (Hexokinase).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Hexokinase 1 (ABIN392759)

Lynn, Wang, Markesbery, Lovell: "Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease." dans: Journal of Alzheimer's disease : JAD, Vol. 19, Issue 1, pp. 325-39, (2010) (PubMed).

Détails sur Hexokinase 1

Antigène: Hexokinase 1 (HK1)

Autre désignation: HK1 (Hexokinase)

Sujet: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus, the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

Poids moléculaire: 102486

ID gène: 3098

NCBI Accession: NP_000179, NP_277031, NP_277032, NP_277033, NP_277035

UniProt: P19367

Pathways: Carbohydrate Homeostasis, L'effet Warburg