PFKFB2 anticorps (N-Term)

N° du produit ABIN392769

Détail du produit anti-PFKFB2 anticorps

Antigène: PFKFB2 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This PFKFB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PFKFB2.

Clone: RB4031-4032

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-PFKFB2 (ABIN392769)

Xia, Hong, Ye, Wang, Chen, Liu: "Label-free quantitative proteomic analysis of right ventricular remodeling in infant Tetralogy of Fallot patients." dans: Journal of proteomics, Vol. 84, pp. 78-91, (2013) (PubMed).

Carlet, Janjetovic, Rainer, Schmidt, Panzer-Grümayer, Mann, Prelog, Meister, Ploner, Kofler: "Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells." dans: BMC cancer, Vol. 10, pp. 638, (2010) (PubMed).

Yalcin, Clem, Simmons, Lane, Nelson, Clem, Brock, Siow, Wattenberg, Telang, Chesney: "Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases." dans: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24223-32, (2009) (PubMed).

Détails sur PFKFB2

Antigène: PFKFB2 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 2 (PFKFB2))

Autre désignation: PFKFB2 (PFKFB2 Produits)

Synonymes: anticorps pfkfb2, anticorps zgc:56282, anticorps PFK-2/FBPase-2, anticorps 4930568D07Rik, anticorps RH2K, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, anticorps pfkfb2a, anticorps PFKFB2, anticorps pfkfb2, anticorps Pfkfb2

Sujet: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Poids moléculaire: 58477

NCBI Accession: NP_001018063, NP_006203

UniProt: O60825

Pathways: Signalisation PI3K-Akt, Positive Regulation of Peptide Hormone Secretion, Regulation of Carbohydrate Metabolic Process