FANCF anticorps (Internal Region)

N° du produit ABIN401270

L’anticorps anti-FANCF Polyclonal Lapin est utilisé pour la détection de FANCF dans des échantillons de Humain et Chimpanzé. Il a été validé pour WB et EIA.

Aperçu rapide pour FANCF anticorps (Internal Region) (ABIN401270)

Antigène: FANCF (Fanconi Anemia, Complementation Group F (FANCF))

Reactivité: Humain, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCF est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-FANCF anticorps

Épitope: Internal Region

Specificité: This affinity purified antibody is directed against FANCF protein.

Réactivité croisée (Details): Species reactivity (expected):Chimpanzee (100 %).
Species reactivity (tested):Human.

Purification: Immunoaffinity chromatography

Immunogène: Synthetic peptide corresponding to an internal amino acid sequence of human FANCF

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1: 15,000 - 1: 60,000. Western blot: 1: 1,000 - 1: 5,000 (Expect a band approximately 42 kDa in size correspondingto FANCF in the appropriate human tissue).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.19 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur FANCF

Antigène: FANCF (Fanconi Anemia, Complementation Group F (FANCF))

Autre désignation: FANCF

Sujet: FANCF (also called Protein FACF or Fanconi Anemia Group F protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCF belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. FANCF is found within the nucleus. Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FACF, Fanconi anemia group F protein

ID gène: 2188

NCBI Accession: NP_073562

UniProt: Q9NPI8

Pathways: Réparation de l'ADN