CBLC anticorps (AA 444-458)

N° du produit ABIN401316

Cet anticorps anti-CBLC Polyclonal Lapin (ABIN401316) détecte spécifiquement CBLC dans WB, IHC (p), IP et EIA. L’anticorps est réactif avec des échantillons de Humain et Chimpanzé.

Aperçu rapide pour CBLC anticorps (AA 444-458) (ABIN401316)

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Reactivité: Humain, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Détail du produit anti-CBLC anticorps

Épitope: AA 444-458

Specificité: This antibody is directed against Cbl-c protein. No reactivity is expected with Cbl-a or Cbl-b.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human, Chimpanzee.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to amino acids 444-458 of Human Cbl-c

Isotype: IgG

Information d'application

Indications d'application: Immunoprecipitation. ELISA: 1/10,000 - 1/50,000. Western Blot: 1/500 - 1/3,000. Immunohistochemistry: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.42 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur CBLC

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Autre désignation: CBLC / RNF57

Sujet: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.Synonyms: CBL-3, CBL-C, CBL3, RING finger protein 57, SH3-binding protein CBL-C, Signal transduction protein CBL-C

ID gène: 23624

NCBI Accession: NP_001124324

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway