MARK2 anticorps (Isoform A, pThr595)

N° du produit ABIN401318

L’anticorps anti-MARK2 Polyclonal Lapin est utilisé pour la détection de MARK2 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache) et Chien. Il a été validé pour WB et EIA.

Aperçu rapide pour MARK2 anticorps (Isoform A, pThr595) (ABIN401318)

Antigène: MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARK2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-MARK2 anticorps

Épitope: Isoform A, pThr595

Specificité: This antibody is directed against the phosphorylated form of MARK2 at thepT595 residue.

Réactivité croisée (Details): Species reactivity (expected):Canine, Bovine, Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to amino acids surrounding T595 of Human MARK2 isoform a. The immunogen peptide was phosphorylated at the residue corresponding to T595

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/1,000 - 1/3,000. Western Blot: 1/250 - 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.6 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur MARK2

Antigène: MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Autre désignation: MARK2

Sujet: This antibody recognizes a regulatory phosphorylation on a kinase that is critical to regulation of microtubules, cell cycle and immune responses. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encode two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gives rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be co-expressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA that is ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein.Synonyms: 2, ELKL motif kinase, EMK1, MAP/microtubule affinity-regulating kinase, MARK2, PAR1 homolog, Serine/threonine-protein kinase

ID gène: 2011

NCBI Accession: NP_001034558

UniProt: Q7KZI7

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2