PML anticorps

N° du produit ABIN452172

Détail du produit anti-PML anticorps

Antigène: PML (Promyelocytic Leukemia (PML))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PML est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognizes normal PML proteins of lower Molecular Weight, and also recognizes the High Molecular Weight PML/RAR-alpha Chimeric protein in promyelocytic leukemia patients.

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: RING finger protein 71, MYL, TRIM19, Probable transcription factor PML, Tripartitemotif-containing protein 19

Purification: Affinity Chromatography on Protein G.

Immunogène: Recombinant partial Human PML.

Clone: B3E9

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: Use PML antibody at 1/2,000 dilution to differentiate normal PML andChimeric PML/RAR alpha molecules based on their molecular weight.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore by adding appropriate volume of distilled water to reach a final antibody concentration of 1.0 mg/mL.

Buffer: 0.01 M PBS, pH 7.4 without preservatives.

Agent conservateur: Without preservative

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. After reconstitution, aliquot and store at -20 °C.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur PML

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: PML / RNF71 (PML Produits)

Synonymes: anticorps MYL, anticorps PP8675, anticorps RNF71, anticorps TRIM19, anticorps 1200009E24Rik, anticorps AI661194, anticorps Trim19, anticorps RGD1562602, anticorps PML, anticorps promyelocytic leukemia, anticorps PML, anticorps Pml

Sujet: PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.Synonyms: MYL, Probable transcription factor PML, RING finger protein 71, TRIM19, Tripartite motif-containing protein 19

ID gène: 5371

UniProt: P29590

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus