M-CSF/CSF1 anticorps

N° du produit ABIN452499

Cet anticorps anti-M-CSF/CSF1 Monoclonal Souris (Clone 116) (ABIN452499) détecte spécifiquement M-CSF/CSF1 dans EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour M-CSF/CSF1 anticorps (ABIN452499)

Antigène: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp M-CSF/CSF1 est non-conjugé

Application: Enzyme Immunoassay (EIA)

Clone: 116

Détail du produit anti-M-CSF/CSF1 anticorps

Specificité: This monoclonal antibody is specifically reactive to rhM-CSF. Does not cross react with BSA or other Human cytokines tested such as IL1 beta, IL-8, IL-16, EGF, G-CSFR, GM-CSF, MCP-1, MCP-3, TGF beta and TNF alpha.

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: CSF-1, CSF1, MCSF, Macrophage colony-stimulating factor 1

Purification: Affinity Chromatography on Protein G.

Immunogène: Purified recombinant Human M-CSF (rhM-CSF).

Isotype: IgG2b

Information d'application

Indications d'application: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with Double distillated water to adjust the final concentration to 1.00 mg/mL

Buffer: 0.01 M PBS, pH 7.2 without preservatives.

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur M-CSF/CSF1

Antigène: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Autre désignation: Macrophage Colony Stimulating Factor (M-CSF)

Sujet: Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).Synonyms: CSF-1, CSF1, MCSF, Macrophage colony-stimulating factor 1

ID gène: 1435

UniProt: P09603

Pathways: Signalisation RTK