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Ly6g anticorps (FITC)

Ly6g Reactivité: Souris FACS Hôte: Rat Monoclonal RB6-8C5 FITC
N° du produit ABIN457353
  • Antigène Tous les produits Ly6g
    Ly6g (Lymphocyte Antigen 6 Complex, Locus G (Ly6g))
    Reactivité
    • 101
    • 13
    • 1
    Souris
    Hôte
    • 80
    • 20
    • 1
    Rat
    Clonalité
    • 80
    • 19
    • 1
    Monoclonal
    Conjugué
    • 26
    • 9
    • 8
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Ly6g est conjugé à/à la FITC
    Application
    • 77
    • 35
    • 30
    • 29
    • 22
    • 17
    • 11
    • 10
    • 9
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The rat monoclonal antibody RB6-8C5 detects Ly6G component of Gr-1 antigen, a commonly used surface marker of neutrophils.
    Réactivité croisée (Details)
    Mouse
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Murine granulocytes
    Clone
    RB6-8C5
    Isotype
    IgG2b
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.

    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Jung, Zindl, Lai, Weaver, Chaplin: "MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways." dans: European journal of immunology, Vol. 39, Issue 8, pp. 2281-92, (2009) (PubMed).

    dos Santos, Vaz Cardoso, Nascimento, Lino, Dorta, de Oliveira, Ribeiro-Dias: "Leishmania major: recruitment of Gr-1+ cells into draining lymph nodes during infection is important for early IL-12 and IFN gamma production." dans: Experimental parasitology, Vol. 119, Issue 3, pp. 403-10, (2008) (PubMed).

    Leendertse, Willems, Giebelen, Roelofs, Bonten, van der Poll: "Neutrophils are essential for rapid clearance of Enterococcus faecium in mice." dans: Infection and immunity, Vol. 77, Issue 1, pp. 485-91, (2008) (PubMed).

    Fan, Li, Levy, Fan, Hackam, Vodovotz, Yang, Tracey, Billiar, Wilson: "Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 10, pp. 6573-80, (2007) (PubMed).

    Koo, Gan: "The innate interferon gamma response of BALB/c and C57BL/6 mice to in vitro Burkholderia pseudomallei infection." dans: BMC immunology, Vol. 7, pp. 19, (2006) (PubMed).

    Nagendra, Schlueter: "Absence of cross-reactivity between murine Ly-6C and Ly-6G." dans: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 58, Issue 2, pp. 195-200, (2004) (PubMed).

    Brown, Blaho, Loiacono: "Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 893-901, (2003) (PubMed).

    Hestdal, Ruscetti, Ihle, Jacobsen, Dubois, Kopp, Longo, Keller: "Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 1, pp. 22-8, (1991) (PubMed).

  • Antigène
    Ly6g (Lymphocyte Antigen 6 Complex, Locus G (Ly6g))
    Autre désignation
    Ly6G (Ly6g Produits)
    Synonymes
    anticorps Gr-1, anticorps Gr1, anticorps Ly-6G, anticorps lymphocyte antigen 6 complex, locus G, anticorps Ly6g
    Sujet
    Lymphocyte antigen 6 complex, locus G,Ly6G is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. Ly6G is a good marker for detection of peripheral neutrophils. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. Physiological role of Ly6G remains still unclear. Its treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses.,Gr1, Gr-1, Ly-6G
    ID gène
    546644
    UniProt
    A0A087WQF5
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