beta Amyloid anticorps (Amyloid beta)

Details for Product anti-Abeta Antibody No. ABIN459388
Antigène
Reactivité
Humain
156
38
27
9
6
5
5
4
3
2
2
1
1
1
1
1
1
Hôte
Souris
98
66
4
2
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp beta Amyloid est non-conjugé
11
4
2
1
1
1
Application
Immunohistochemistry (IHC), ELISA
115
93
57
38
33
32
21
16
11
5
5
3
2
1
1
1
1
1
1
Options
Immunogène partly aggregated, recombinant peptide corresponding to the human Abeta (1-40/42). Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V. The epitope is 3-8.
Clone OMAB
Isotype IgM
Réactivité croisée (Details) Not reactive in: no confirmed exceptions from predicted reactivity known in the moment
Homologie rat
Attributs du produit Expected / apparent Molecular Weight of the Antigene: 4.5 kDa
OMAB antibody is a versatile tool within research of Alzheimer’s disease. A sandwhich ELISA illustrates its potential regarding its high selectivity towards Aβ oligomers. OMAB antibody has been purified by by ion-exchange chromatography.
Purification affinity purified
Antigène
Autre désignation Amyloid beta oligomer-specific (Abeta Antibody Extrait)
Sujet Soluble oligomeric assemblies of the Amyloid-β peptide are today anticipated to be the direct cause regarding the Alzheimer pathology. As a consequence, oligomeric Aβ-assemblies constitute a very interesting therapeutic target. Identification of Aβ-oligomers is however, technically challenging due to there labile nature and low abundance. Abeta oligomer-specific OMAB antibody is based on the IgM isotype and represents a new concept of Aβ-oligomer binders using a combination of high avidity and very low monovalent affinity. This combination creates a selectivity of the antibody towards the oligomeric fraction and minimizes reactivity towards monomeric species.
Poids moléculaire 4.5 kDa
Indications d'application coating antibody at 2 μg/mL (ELISA), 1: 500 (IHC)
Commentaires

OMAB antibody is a versatile tool within research of Alzheimer's disease. A sandwhich ELISA illustrates its potential regarding its high selectivity towards Aβ oligomers.

Restrictions For Research Use only
Format Lyophilized
Reconstitution For reconstitution add 100 μL of sterile water.
Buffer PBS without any additives as carrier proteins or sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Stock 4 °C
Stockage commentaire store lyophilized/reconstituted at 4°C. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Images (Fournisseur)
Image no. 1 for anti-Amyloid beta (Abeta) antibody (ABIN459388) Abeta oligomer-specific antibody was adsorbed to Nunc-Immuno MaxiSorp plates (Nunc, R...
Image no. 2 for anti-Amyloid beta (Abeta) antibody (ABIN459388) 10 µm of coronal sections from fresh-frozen transgenic mouse brain mutant (A) and wil...