FOXP3 anticorps

N° du produit ABIN487427

L’anticorps anti-FOXP3 Monoclonal Souris est utilisé pour la détection de FOXP3 dans des échantillons de Humain et Souris. Il a été validé pour WB et FACS.

Aperçu rapide pour FOXP3 anticorps (ABIN487427)

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXP3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 3G3

Détail du produit anti-FOXP3 anticorps

Specificité: The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor, which is the master regulator in the development and function of regulatory T cells.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Attributs du produit: Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

Purification: Protein A affinity chromatography

Immunogène: Full-length His-tagged recombinant murine FoxP3

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry (Application note see below). Western blot: 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur FOXP3

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Autre désignation: FOXP3

Sujet: FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

ID gène: 20371

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation