CRYAA anticorps (AA 1-173)

N° du produit ABIN4886549

Détail du produit anti-CRYAA anticorps

Antigène: CRYAA (Crystallin, alpha A (CRYAA))

Épitope: AA 1-173

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRYAA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Alpha-crystallin A chain(CRYAA) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Alpha-crystallin A chain(CRYAA) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: crystallin alpha A
Protein Name: Alpha-crystallin A chain

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Alpha A Crystallin recombinant protein (Position: M1-S173). Human Alpha A Crystallin shares 94.8% amino acid (aa) sequence identity with both mouse and rat Alpha A Crystallin.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur CRYAA

Antigène: CRYAA (Crystallin, alpha A (CRYAA))

Autre désignation: CRYAA (CRYAA Produits)

Synonymes: anticorps CRYA1, anticorps CTRCT9, anticorps HSPB4, anticorps AI323437, anticorps Acry-1, anticorps Crya-1, anticorps Crya1, anticorps DAcry-1, anticorps lop18, anticorps alpha-a-crystallin, anticorps cryaa-A, anticorps CRYAA, anticorps wu:fc06h04, anticorps zgc:92036, anticorps HspB4, anticorps crystallin alpha A, anticorps crystallin, alpha A, anticorps alphaA-crystallin, anticorps alpha-crystallin A chain-like, anticorps crystallin alpha A S homeolog, anticorps alpha-crystallin A chain, anticorps CRYAA, anticorps Cryaa, anticorps CpipJ_CPIJ005646, anticorps cryaa, anticorps LOC100384978, anticorps cryaa.S, anticorps LOC458589, anticorps LOC102724652

Sujet: Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

Synonyms: Acry 1 | CRYA 1 | CRYA1 | CRYAA | Crystallin alpha 1 | Crystallin alpha A | HSPB 4 | HspB4 | P02489

ID gène: 1409

UniProt: P02489

Pathways: M Phase