beta Amyloid anticorps (AA 221-270)

N° du produit ABIN4900974

Cet anticorps anti-beta Amyloid est un anticorps Lapin Polyclonal détectant beta Amyloid dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour beta Amyloid anticorps (AA 221-270) (ABIN4900974)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-beta Amyloid anticorps

Épitope: AA 221-270

Fonction: Amyloid-β is a protein encoded by the APP gene which is approximately 86,9 kDa. Amyloid-β is localised to the cell membrane. It is involved in activated TLR4 signalling, peptide ligand-binding receptors and A-beta pathways including plaque formation and APP metabolism. It functions as a cell surface receptor that performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It plays a role in cell mobility and transcription regulation through protein-protein interactions. Amyloid-β is expressed in the cerebrospinal fluid, brain, liver and all foetal tissues. Mutations in the APP gene may be implicated in Alzheimer disease. STJ98585 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous levels of Amyloid-β.

Specificité: Amyloid-β Polyclonal Antibody detects endogenous levels of Amyloid-β

Attributs du produit: Rabbit Polyclonal to Amyloid-β.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from Amyloid-beta

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000
ELISA 1:10000-20000

Commentaires:

Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid-beta

ID gène: 351

UniProt: P05067

Pathways: Inflammasome