MAP1LC3A anticorps

N° du produit ABIN4901877

Cet anticorps anti-MAP1LC3A Monoclonal Souris (Clone 5G10) (ABIN4901877) détecte spécifiquement MAP1LC3A dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MAP1LC3A anticorps (ABIN4901877)

Antigène: MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP1LC3A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5G10

Détail du produit anti-MAP1LC3A anticorps

Fonction: LC3A is a protein encoded by the MAP1LC3A gene which is approximately 14,3 kD. LC3A is localised to the cytoplasm, cytoskeleton and autophagosome. It is involved in pathways such as the autophagy pathway, pink/parkin mediated mitophagy, ferroptosis, cellular senescence and pathways affecting insulin-like growth factor-Akt signalling. MAP1A and MAP1B fall under the LC3A protein. They are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Mutations in the LC3A gene may result in Nasu-Hakola disease , lacrimal gland adenocarcinoma and leber congenital amaurosis. STJ97755 was developed from clone 5G10. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous levels of LC3A.

Specificité: LC3A Mouse Monoclonal Antibody (5G10) detects endogenous levels of LC3A

Attributs du produit: Mouse Monoclonal to LC3A.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogène: synthetic peptide derived from LC3A

Isotype: IgG1

Information d'application

Indications d'application: WB 1:1000-2000
IHC 1:100-200

Commentaires:

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur MAP1LC3A

Antigène: MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))

Autre désignation: LC3A

ID gène: 84557

UniProt: Q9H492

Pathways: Autophagy