BBS4 anticorps

N° du produit ABIN4906487

L’anticorps Souris Monoclonal anti-BBS4 a été validé pour WB. Il convient pour détecter BBS4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BBS4 anticorps (ABIN4906487)

Antigène: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BBS4 est non-conjugé

Application: Western Blotting (WB)

Clone: 2C8

Détail du produit anti-BBS4 anticorps

Réactivité croisée: Humain, Souris, Rat

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This BBS4 antibody is generated from a mice immunized with a recombinant protein between 1-240 amino acids from human BBS4.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur BBS4

Antigène: BBS4 (Bardet-Biedl Syndrome 4 (BBS4))

Autre désignation: BBS4

Sujet:

Synonyms: Bardet-Biedl syndrome 4 protein, BBS4

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.

ID gène: 585

UniProt: Q96RK4

Pathways: Signalisation Hedgehog, Tube Formation, Maintenance of Protein Location