EPH Receptor A5 anticorps

N° du produit ABIN4909184

L’anticorps Souris Monoclonal anti-EPH Receptor A5 a été validé pour WB et IHC (p). Il convient pour détecter EPH Receptor A5 dans des échantillons de Humain.

Aperçu rapide pour EPH Receptor A5 anticorps (ABIN4909184)

Antigène: EPH Receptor A5 (EPHA5)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EPH Receptor A5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6C4

Détail du produit anti-EPH Receptor A5 anticorps

Réactivité croisée: Humain

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: Purified His-tagged EPHA5 protein(Fragment) was used to produced this monoclonal antibody.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur EPH Receptor A5

Antigène: EPH Receptor A5 (EPHA5)

Autre désignation: EPHA5

Sujet:

Synonyms: EK7, CEK7, EHK1, HEK7, EHK-1, TYRO4, Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EPH-like kinase 7, EPHA5, BSK

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

ID gène: 2044

UniProt: P54756

Pathways: Signalisation RTK