FZR1 anticorps

N° du produit ABIN4909759

Cet anticorps Souris Monoclonal détecte spécifiquement FZR1 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour FZR1 anticorps (ABIN4909759)

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FZR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 1C7

Détail du produit anti-FZR1 anticorps

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000
IF()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur FZR1

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Autre désignation: FZR

Sujet:

Synonyms: FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

ID gène: 51343

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA