PKM2 anticorps

N° du produit ABIN4953284

Cet anticorps anti-PKM2 est un anticorps Souris Monoclonal détectant PKM2 dans WB, IF et ICC. Adapté pour Humain, Souris, Rat et Primate.

Aperçu rapide pour PKM2 anticorps (ABIN4953284)

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivité: Humain, Souris, Rat, Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PKM2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 1A7-G6-H6

Détail du produit anti-PKM2 anticorps

Purification: Protein G affinity

Immunogène: A human recombinant partial protein was used as the immunogen for this PKM2 antibody.

Isotype: IgG1

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the PKM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,ICC/IF: 1:400

Restrictions: For Research Use only

Stockage

Buffer: Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300

Stock: -20 °C

Stockage commentaire: Store the PKM2 antibody at -20°C.

Détails sur PKM2

Antigène: PKM2 (Pyruvate Kinase M2 (PKM2))

Autre désignation: Pyruvate Kinase / PKM2

Sujet: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]

UniProt: P14618

Pathways: L'effet Warburg