Androgen Receptor anticorps

N° du produit ABIN3029944

Cet anticorps Souris Monoclonal détecte spécifiquement Androgen Receptor dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour Androgen Receptor anticorps (ABIN3029944)

Antigène: Androgen Receptor (AR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 549CT16-1-4

Détail du produit anti-Androgen Receptor anticorps

Purification: Purified

Immunogène: Purified His-tagged protein fragment was used to produced this monoclonal anti-Androgen Receptor antibody.

Isotype: IgA

Information d'application

Indications d'application: Titration of the anti-Androgen Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the anti-Androgen Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: Androgen Receptor

Sujet: Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor, sumoylation of AR represses AR-dependent transcription.

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding