APP anticorps (AA 333-362)

N° du produit ABIN3029927

L’anticorps Lapin Polyclonal anti-APP a été validé pour WB, ELISA, IHC et IF. Il convient pour détecter APP dans des échantillons de Humain.

Aperçu rapide pour APP anticorps (AA 333-362) (ABIN3029927)

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-APP anticorps

Épitope: AA 333-362

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 333-362 from the human protein was used as the immunogen for this anti-APP antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the anti-APP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the anti-APP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur APP

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Autre désignation: APP

Sujet: The APP gene encodes Amyloid beta, a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour