ATG7 anticorps (AA 284-313)

N° du produit ABIN3029987

Détail du produit anti-ATG7 anticorps

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Épitope: AA 284-313

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée (Details): Expected species reactivity: Rat, Chicken

Purification: Purified

Immunogène: A portion of amino acids 284-313 from the human protein was used as the immunogen for this APG7 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the APG7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the APG7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ATG7

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Autre désignation: ATG7 (APG7) (ATG7 Produits)

Synonymes: anticorps APG7-LIKE, anticorps APG7L, anticorps GSA7, anticorps D8, anticorps UBA1B, anticorps UBE1L, anticorps UBE2, anticorps Ube1l, anticorps 1300004C08Rik, anticorps AO090001000744, anticorps atg7, anticorps 1810013K23Rik, anticorps Agp7, anticorps Apg7l, anticorps Atg7l, anticorps ATAPG7, anticorps ATATG7, anticorps ATG7, anticorps AUTOPHAGY 7, anticorps AUTOPHAGY-RELATED 7, anticorps K15I22.10, anticorps K15I22_10, anticorps autophagy related 7, anticorps ubiquitin like modifier activating enzyme 7, anticorps ubiquitin-like modifier activating enzyme 7, anticorps autophagy-related protein 7, anticorps Autophagy-related protein 7, anticorps Apg7p, anticorps ThiF family protein, anticorps ubiquitin-like conjugating enzyme Atg7, anticorps ATG7, anticorps UBA7, anticorps Uba7, anticorps ANI_1_3368024, anticorps AOR_1_1338164, anticorps PTRG_02236, anticorps PAAG_00287, anticorps PITG_12537, anticorps atg7, anticorps Atg7, anticorps APG7

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

UniProt: O95352

Pathways: Response to Water Deprivation, Autophagy