C4B anticorps (AA 655-684)

N° du produit ABIN3030240

Cet anticorps anti-C4B est un anticorps Lapin Polyclonal détectant C4B dans WB et ELISA. Adapté pour Souris.

Aperçu rapide pour C4B anticorps (AA 655-684) (ABIN3030240)

Antigène: C4B (C4b) (Complement Component C4b (C4b))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C4B est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-C4B anticorps

Épitope: AA 655-684

Réactivité croisée (Details): Expected species reactivity: Human

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 655-684 from the human protein was used as the immunogen for this C4B antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the C4B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the C4B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur C4B

Antigène: C4B (C4b) (Complement Component C4b (C4b))

Autre désignation: C4B (Complement 4b)

Sujet: This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

UniProt: P0C0L4

Pathways: Système du Complément