CD40 anticorps (AA 247-276)

N° du produit ABIN3030395

L’anticorps Lapin Polyclonal anti-CD40 a été validé pour WB et ELISA. Il convient pour détecter CD40 dans des échantillons de Humain.

Aperçu rapide pour CD40 anticorps (AA 247-276) (ABIN3030395)

Antigène: CD40

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CD40 anticorps

Épitope: AA 247-276

Réactivité croisée (Details): Expected species reactivity: Mouse, Pig

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 247-276 from the human protein was used as the immunogen for this CD40 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the CD40 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CD40 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

UniProt: P25942

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints