DDX58 anticorps (AA 585-614)

N° du produit ABIN3030700

Cet anticorps Lapin Polyclonal détecte spécifiquement DDX58 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour DDX58 anticorps (AA 585-614) (ABIN3030700)

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDX58 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DDX58 anticorps

Épitope: AA 585-614

Fonction: DDX58 Antibody / RIG-I

Purification: Purified

Immunogène: A portion of amino acids 585-614 from the human protein was used as the immunogen for this DDX58 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the DDX58 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the DDX58 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur DDX58

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Autre désignation: DDX58

Sujet: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I/DDX58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.

UniProt: O95786

Pathways: Activation of Innate immune Response, Hepatitis C