PARK7/DJ1 anticorps (AA 1-30)

N° du produit ABIN3032158

Cet anticorps Lapin Polyclonal détecte spécifiquement PARK7/DJ1 dans WB, ELISA et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour PARK7/DJ1 anticorps (AA 1-30) (ABIN3032158)

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARK7/DJ1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-PARK7/DJ1 anticorps

Épitope: AA 1-30

Réactivité croisée (Details): Expected species reactivity: Bovine, Zebrafish

Purification: Purified

Immunogène: A portion of amino acids 1-30 from the human protein was used as the immunogen for this DJ-1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the DJ-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the DJ-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur PARK7/DJ1

Antigène: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Autre désignation: DJ-1

Sujet: Park7/DJ-1 acts as positive regulator of androgen receptor-dependent transcription, and may function as redox-sensitive chaperone and as sensor for oxidative stress, as well as preventing aggregation of SNCA. This protein has been shown to protect neurons against oxidative stress and cell death, and to play a role in fertilization. It is detected in tau inclusions in brains from neurodegenerative disease patients, and is generally highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart, with detectable levels in placenta, brain, astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in Park7/DJ-1 are the cause of autosomal recessive early-onset Parkinson disease 7, a form of Parkinson disease characterized by onset before 40 years, slow progression and initial good response to levodopa.

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport