EPH Receptor B1 anticorps (AA 374-409)

N° du produit ABIN3030823

Cet anticorps Lapin Polyclonal détecte spécifiquement EPH Receptor B1 dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor B1 anticorps (AA 374-409) (ABIN3030823)

Antigène: EPH Receptor B1 (EPHB1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-EPH Receptor B1 anticorps

Épitope: AA 374-409

Réactivité croisée (Details): Expected species reactivity: Chicken

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 374-409 from the mouse protein were used as the immunogen for the Ephb1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Ephb1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Ephb1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur EPH Receptor B1

Antigène: EPH Receptor B1 (EPHB1)

Autre désignation: Ephb1

Sujet: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

UniProt: Q8CBF3

Pathways: Signalisation RTK