ERCC1 anticorps (AA 268-297)

N° du produit ABIN3030896

Détail du produit anti-ERCC1 anticorps

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Épitope: AA 268-297

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 268-297 from the human protein was used as the immunogen for this ERCC1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the ERCC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ERCC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1 (ERCC1 Produits)

Synonymes: anticorps COFS4, anticorps RAD10, anticorps UV20, anticorps Ercc-1, anticorps ercc1, anticorps T12H1.18, anticorps T12H1_18, anticorps UV REPAIR DEFICIENT 7, anticorps UVR7, anticorps ERCC excision repair 1, endonuclease non-catalytic subunit, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 1, anticorps DNA excision repair protein ERCC-1, anticorps nucleotide repair protein, anticorps excision repair cross-complementation group 1 L homeolog, anticorps excision repair cross-complementation group 1, anticorps ERCC1, anticorps Ercc1, anticorps CC1G_04546, anticorps CpipJ_CPIJ013903, anticorps PITG_13719, anticorps ercc1, anticorps ercc1.L

Sujet: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

UniProt: P07992

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response