FBXW7 anticorps (N-Term)

N° du produit ABIN3030899

L’anticorps Lapin Polyclonal anti-FBXW7 a été validé pour WB et ELISA. Il convient pour détecter FBXW7 dans des échantillons de Humain.

Aperçu rapide pour FBXW7 anticorps (N-Term) (ABIN3030899)

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW7 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FBXW7 anticorps

Épitope: N-Term

Purification: Antigen affinity purified

Immunogène: This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the FBXW7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the FBXW7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur FBXW7

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Autre désignation: FBXW7

Sujet: Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt]

UniProt: Q969H0

Pathways: Signalisation Notch, EGFR Signaling Pathway